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Prostate cancer is the most common cancer in men, with approximately 50,000 new cases diagnosed each year in France. When a father, brother, uncle, or other close relative has been affected, the same question often arises: is there a prostate cancer gene?<\/strong><\/p>\n The answer is nuanced. Yes, there are identified genetic predispositions<\/a><\/strong> . No, simply having a case of prostate cancer in the family does not automatically mean that one is personally at significant hereditary risk.<\/p>\n The challenge, therefore, is to clearly distinguish between ordinary situations and those that should raise the possibility of a family history<\/strong> and justify a specialist evaluation.<\/p>\n Yes, in some cases. Among the risk factors for prostate cancer, there is indeed a hereditary risk factor<\/strong> .<\/p>\n To date, two genes have been specifically identified in this predisposition:<\/p>\n These names may seem technical, but they are important because their presence is associated with prostate cancer:<\/p>\n In other words, when a true genetic predisposition exists, it not only changes the probability of developing cancer, but can also influence the age at which it appears and its behavior.<\/p>\n This is a crucial point. Many men become concerned as soon as a family member has had prostate cancer. This concern is understandable, but it's important to avoid jumping to conclusions.<\/p>\n An isolated case in the family is not, by itself, sufficient to conclude that there is a genetic predisposition.<\/strong><\/p>\n To suspect a hereditary predisposition, specific family criteria<\/strong> are relied upon. These criteria then guide the patient towards an oncogenetic consultation<\/a> .<\/p>\n The most telling situations are the following:<\/p>\n These cases must concern relatives described as:<\/p>\n The idea is therefore not just to count the cases, but also to look at the age at diagnosis<\/strong> and the degree of kinship<\/strong> .<\/p>\n When people talk about prostate cancer, many spontaneously think of the paternal lineage. This is a common mistake.<\/p>\n Maternal heredity also plays a role.<\/strong> Certain family histories on the mother's side can point towards a genetic predisposition associated with prostate risk.<\/p>\n Particular attention should be paid to:<\/p>\n These antecedents, on both the maternal and paternal sides, may be part of a family context compatible with a genetic anomaly, particularly around the BRCA2<\/a><\/strong> gene.<\/p>\n Can prostate cancer be genetic?<\/h2>\n
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Having a close relative affected does not necessarily mean you are at genetic risk.<\/h2>\n
What family history should suggest a genetic predisposition?<\/h2>\n
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We also need to look at the maternal side<\/h2>\n
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What should you do if you think you have a hereditary risk?<\/h2>\n