{"id":4935,"date":"2026-06-08T09:50:00","date_gmt":"2026-06-08T08:50:00","guid":{"rendered":"https:\/\/www.dumonceau-urologie.fr\/urology\/having-a-prostate-biopsy-why-how-and-is-it-painful\/"},"modified":"2026-09-06T22:36:33","modified_gmt":"2026-09-06T21:36:33","slug":"having-a-prostate-biopsy-why-how-and-is-it-painful","status":"publish","type":"post","link":"https:\/\/www.dumonceau-urologie.fr\/en\/urology\/having-a-prostate-biopsy-why-how-and-is-it-painful\/","title":{"rendered":"Having a prostate biopsy: why, how, and is it painful?"},"content":{"rendered":"<p><img decoding=\"async\" width=\"100%\" src=\"https:\/\/www.dumonceau-urologie.fr\/wp-content\/uploads\/2026\/04\/faire-une-biopsie-prostate-pourquoi-comment-est-ce-douloureux-vtb-69e238293659c.jpg\" alt=\"Video thumbnail for &#39;Undergoing a prostate biopsy: why? how? Is it painful?&#39;\" style=\"max-width: 100%;height: auto\"><\/p>\n<p> When a <a href=\"https:\/\/fr.wikipedia.org\/wiki\/Antig%C3%A8ne_prostatique_sp%C3%A9cifique\" target=\"_blank\" rel=\"noopener\">PSA<\/a> level is abnormal or a clinical examination of the prostate is not reassuring, a prostate MRI may be performed. If this MRI reveals a <strong><a href=\"https:\/\/www.urofrance.org\/fichebasecongres\/biopsies-prostatiques-ciblees-guidees-par-irm-experience-clinique-initiale-dune-plateforme-de-fusion-echo-irm\/\" target=\"_blank\" rel=\"noopener\">target area<\/a><\/strong> , the question of a <strong>prostate biopsy<\/strong> then becomes very clear.<\/p>\n<p> For many men, this is a worrying test. Is it really necessary? What exactly are they looking for? How is it actually performed? And above all, should they expect a painful test?<\/p>\n<p> The prostate biopsy has a simple but fundamental objective: <strong>to determine if there is prostate cancer<\/strong> , and if so, <strong>to assess its aggressiveness<\/strong> in order to choose the most appropriate treatment.<\/p>\n<h2> Why a prostate biopsy is sometimes necessary<\/h2>\n<p> The biopsy is not performed randomly. It usually takes place after a stage of suspicion.<\/p>\n<p> The most frequent scenario is as follows:<\/p>\n<ul>\n<li> <strong>abnormal PSA<\/strong><\/li>\n<li> <strong>Abnormal clinical examination<\/strong><\/li>\n<li> <strong>MRI of the prostate<\/strong> showing a suspicious lesion, called a target area<\/li>\n<\/ul>\n<p> In this situation, MRI provides guidance, but it is not sufficient on its own to make a definitive diagnosis. Only a biopsy allows for the removal of prostate tissue for microscopic analysis.<\/p>\n<p> In other words, the biopsy serves to answer the essential question: <strong>is there cancer, yes or no?<\/strong><\/p>\n<h2> What the biopsy is really looking for<\/h2>\n<p> It is often thought that a biopsy is only used to detect the presence of cancer. This is true, but it is only part of its purpose.<\/p>\n<p> Analyzing the samples helps answer two main questions:<\/p>\n<ol>\n<li> <strong>Is there such a thing as prostate cancer?<\/strong><\/li>\n<li> <strong>If so, what is its level of local aggressiveness?<\/strong><\/li>\n<\/ol>\n<p> This second question is crucial, because not all prostate cancers are the same. Some are slow-growing and can be managed with monitoring. Others, on the contrary, require more active treatment.<\/p>\n<h2> How is a prostate biopsy performed today?<\/h2>\n<p> The current technique relies on an increasingly precise approach. The biopsy is performed <strong>under ultrasound guidance<\/strong> , with a <strong>fusion of MRI- <a href=\"https:\/\/www.philips.com\/healthcare\/product\/HC784026\/uronav-mr-ultraschall-gefhrtes-fusionsbiopsiesystem\" target=\"_blank\" rel=\"noopener\">ultrasound<\/a> <a href=\"https:\/\/www.urofrance.org\/fichebasecongres\/interet-de-lechographie-3d-et-fusion-dimage-irm-pour-le-diagnostic-du-cancer-de-la-prostate\/\" target=\"_blank\" rel=\"noopener\">images<\/a><\/strong> .<\/p>\n<p> In practice, the MRI images are transferred to the ultrasound. This allows for a three-dimensional visualization of the prostate and precise localization of the target area identified on the MRI.<\/p>\n<p> The objective is clear: <strong>to take samples exactly from the suspect area<\/strong> , rather than taking samples blindly.<\/p>\n<p> This precision improves the diagnostic quality of the examination and allows for better characterization of any potential lesion.<\/p>\n<h2> Which path does the needle take?<\/h2>\n<p> Today, prostate biopsies are performed via <strong><a href=\"https:\/\/www.chuv.ch\/fr\/offre-en-soins\/maladies\/examens\/examen\/web_exm_2\/biopsie-de-la-prostate-par-voie-transperineale\" target=\"_blank\" rel=\"noopener\">the perineal route<\/a><\/strong> , that is, through the skin located in front of the anus.<\/p>\n<p> This development is important. The transrectal route, long used, is now much less common because it posed a greater risk of infection.<\/p>\n<p> The perineal route has therefore become the reference in this safety logic.<\/p>\n<h2> Local anesthesia or short general anesthesia<\/h2>\n<p> Depending on the circumstances, the examination may be carried out:<\/p>\n<ul>\n<li> <strong>under local anesthesia<\/strong><\/li>\n<li> <strong>or under short general anesthesia<\/strong><\/li>\n<\/ul>\n<p> The choice depends on the organization, the habits of the medical team, and the context of each patient.<\/p>\n<p> When wondering if a biopsy is painful, it&#39;s important to understand that the procedure is carefully managed to minimize discomfort. The use of <a href=\"https:\/\/vitrinelinguistique.oqlf.gouv.qc.ca\/fiche-gdt\/fiche\/17027906\/anesthesie-locale\" target=\"_blank\" rel=\"noopener\">local<\/a> or short-acting general anesthesia serves this purpose.<\/p>\n<h2>\n<div style=\"text-align:center\"> <iframe title=\"Faire une biopsie prostate: pourquoi ? comment? Est-ce douloureux ?\" width=\"800\" height=\"450\" src=\"https:\/\/www.youtube.com\/embed\/7NRCpYMSw2A?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/p>\n<\/h2>\n<h2> What happens to the samples after the biopsy?<\/h2>\n<p> Once the samples have been taken, they are analyzed by an <strong><a href=\"https:\/\/www.larousse.fr\/encyclopedie\/medical\/anatomopathologie\/11138\" target=\"_blank\" rel=\"noopener\">anatomopathologist<\/a><\/strong> , that is to say a doctor specializing in the study of tissues under a microscope.<\/p>\n<p> It is this analysis that allows the final diagnosis to be established.<\/p>\n<p> Two situations can then arise.<\/p>\n<h3> 1. There is no cancer<\/h3>\n<p> If no cancer is found, this is obviously reassuring news. In this case, no further cancer treatment is undertaken, but appropriate <strong>monitoring<\/strong> continues.<\/p>\n<h3> 2. A cancer is identified<\/h3>\n<p> If biopsies reveal cancer, the analysis does not stop at this simple observation. It will allow for its <strong>specific identification<\/strong> and evaluation.<\/p>\n<p> Several elements are then studied.<\/p>\n<h2> What biopsies can reveal in the case of cancer<\/h2>\n<h3> The number of positive biopsies<\/h3>\n<p> First question: <strong>how many samples contain cancer?<\/strong><\/p>\n<p> This point is important because it provides information on the local extent of the damage.<\/p>\n<h3> The location of the cancer in the prostate<\/h3>\n<p> We also want to know:<\/p>\n<ul>\n<li> if only biopsies of the <strong>target area<\/strong> are positive<\/li>\n<li> or if cancer is also found <strong>elsewhere in the prostate<\/strong><\/li>\n<li> if the cancer affects <strong>only one lobe<\/strong><\/li>\n<li> or <strong>both lobes<\/strong><\/li>\n<\/ul>\n<p> This information helps to better understand the distribution of cancer within the prostate gland.<\/p>\n<h3> The aggressiveness of tumor cells<\/h3>\n<p> The other major piece of information provided by the biopsy is the degree of aggressiveness of the cancer. This is where the <strong><a href=\"https:\/\/www.urofrance.org\/lafu-academie\/formation-du-college\/referentiel-du-college-durologie-6eme-edition\/chapitre-16-item-310-tumeurs-de-la-prostate\/\" target=\"_blank\" rel=\"noopener\">Gleason score<\/a><\/strong> comes in, sometimes written in different ways but corresponding to the same concept.<\/p>\n<p> The principle is simple:<\/p>\n<ul>\n<li> <strong>The lower the Gleason score, the less aggressive the cancer.<\/strong><\/li>\n<li> <strong>The higher it is, the more aggressive the cancer is.<\/strong><\/li>\n<\/ul>\n<h2> Understanding the Gleason score<\/h2>\n<p> The Gleason score is often written as an addition, for example <strong>3 + 3<\/strong> , <strong>3 + 4<\/strong> or <strong>4 + 4<\/strong> .<\/p>\n<p> Why an addition? Because it is the sum of <strong>two grades<\/strong> :<\/p>\n<ul>\n<li> the most frequent grade in the tumor<\/li>\n<li> the most aggressive grade found<\/li>\n<\/ul>\n<p> Each grade ranges from <strong>3 to 5<\/strong> :<\/p>\n<ul>\n<li> <strong>3<\/strong> corresponds to the least aggressive profile<\/li>\n<li> <strong>5<\/strong> corresponds to the most aggressive profile<\/li>\n<\/ul>\n<p> The total amount therefore ranges from:<\/p>\n<ul>\n<li> <strong>3 + 3 = 6<\/strong><\/li>\n<li> up to <strong>5 + 5 = 10<\/strong><\/li>\n<\/ul>\n<p> This score is a central element of the biopsy report, as it directly contributes to the risk assessment.<\/p>\n<h2> The ISUP score: the classification often used today<\/h2>\n<p> In many centers, the Gleason score is now supplemented or replaced in routine practice by the <strong><a href=\"https:\/\/www.urofrance.org\/lafu-academie\/formation-du-college\/referentiel-du-college-durologie-6eme-edition\/chapitre-16-item-310-tumeurs-de-la-prostate\/\" target=\"_blank\" rel=\"noopener\">ISUP score<\/a><\/strong> , which corresponds to an international classification.<\/p>\n<p> The principle is to group cancers into five categories of increasing risk:<\/p>\n<ul>\n<li> <strong>ISUP 1<\/strong> corresponds to <strong>Gleason 3 + 3<\/strong><\/li>\n<li> then the classification progresses up to <strong>ISUP 5<\/strong><\/li>\n<\/ul>\n<p> This presentation is often simpler to read and use to guide therapeutic decisions.<\/p>\n<h2> Why these results are so important for what comes next<\/h2>\n<p> A biopsy is not just used to label a diagnosis. It allows us to <strong>determine the local aggressiveness of the cancer<\/strong> and to develop a coherent strategy.<\/p>\n<p> To do this, the results of the biopsies are cross-referenced with other data:<\/p>\n<ul>\n<li> the <strong>PSA<\/strong><\/li>\n<li> the results of the <strong>prostate MRI<\/strong><\/li>\n<li> possibly <strong>other additional tests<\/strong> if necessary<\/li>\n<\/ul>\n<p> All of this information allows for a <strong>precise assessment of prostate cancer<\/strong> and the selection of the right treatment option.<\/p>\n<p> It is this comprehensive approach that helps to avoid two pitfalls:<\/p>\n<ul>\n<li> <strong>over-treating<\/strong> a low-grade cancer<\/li>\n<li> <strong>subcontracting<\/strong> a more advanced cancer<\/li>\n<\/ul>\n<h2> Key takeaways<\/h2>\n<p> If you are offered a prostate biopsy after an abnormal PSA level, an abnormal digital rectal exam, or an MRI showing a target area, it is not a routine test done out of excessive caution. It is a key test to obtain a reliable answer.<\/p>\n<ul>\n<li> It helps determine <strong>if cancer is present.<\/strong><\/li>\n<li> It precisely targets the suspicious area thanks to <strong>MRI-ultrasound fusion.<\/strong><\/li>\n<li> Today, it is performed via <strong>the perineal route<\/strong> , in order to reduce the risk of infection.<\/li>\n<li> It can be performed under <strong>local anesthesia<\/strong> or <strong>short general anesthesia<\/strong><\/li>\n<li> It specifies the <strong>local extent<\/strong> and <strong>aggressiveness<\/strong> of the cancer<\/li>\n<li> It provides essential elements such as the <strong>Gleason score<\/strong> or the <strong>ISUP score<\/strong><\/li>\n<\/ul>\n<p> In practice, biopsy is often the decisive step that allows us to move from a simple suspicion to a clear, personalized medical decision adapted to the reality of your situation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>When a PSA level is abnormal or a clinical examination of the prostate is not reassuring, a prostate MRI may be performed. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4647,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[42],"tags":[],"class_list":["post-4935","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-urology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.dumonceau-urologie.fr\/en\/wp-json\/wp\/v2\/posts\/4935","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dumonceau-urologie.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.dumonceau-urologie.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.dumonceau-urologie.fr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dumonceau-urologie.fr\/en\/wp-json\/wp\/v2\/comments?post=4935"}],"version-history":[{"count":0,"href":"https:\/\/www.dumonceau-urologie.fr\/en\/wp-json\/wp\/v2\/posts\/4935\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dumonceau-urologie.fr\/en\/wp-json\/wp\/v2\/media\/4647"}],"wp:attachment":[{"href":"https:\/\/www.dumonceau-urologie.fr\/en\/wp-json\/wp\/v2\/media?parent=4935"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.dumonceau-urologie.fr\/en\/wp-json\/wp\/v2\/categories?post=4935"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.dumonceau-urologie.fr\/en\/wp-json\/wp\/v2\/tags?post=4935"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}